Green Fluorescent Protein in Transgenic Mice
Transgenic Mouse Models of Human Diseases
Transgenic mouse strategies are significant tools for modeling human diseases in animals. The availability of such animal models are key to understand the pathogenesis and to evaluate therapeutic strategies for human diseases. To this goal, we have adopted transgenic mouse approaches in our research for many years. In particular, we have utilized non-toxic fluorescent proteins as markers in our studies. These markers allow us to follow the expression of a co-expressed transgene in cells and tissues, during normal development and physiology and courses of the diseases. The following pictures show various applications of such strategy in tissue-specific expression and germline transmission of GFP transgenes.
Figure 8. TSPY-directed GFP transgene expression in the secondary follicles of a transgenic mouse.