Mpeak: A model-based peak detection software for ChIP-Chip data
Ming Zheng, Ph.D. Stanford University
Mpeak is a simple and efficient computer program, developed in Microsoft Visual C++ 2008 in Win7/WinXP environment, for detection of binding peaks in ChIP-Chip datasets. It utilizes advanced statistical computation, but yet offers a simple procedure with user inputs on parameters in its operation. The Mpeak fitted signals are tabulation in convenient formats and can be visualized in various genome-display graphic programs, including SignalMap and Genome Browser. Mpeak development and uses have been described in the following articles:
Zheng M, Barrera LO, Ren B and Wu YN (2007). ChIP-chip: Data, Model and Analysis. Biometrics, 63:787-796.
Kim TH, Barrera LO, Zheng M, Qu C, Singer MA, Richmand TA, Wu YN, Green RD and Ren B (2005). A high-resolution map of active promoters in the human genome. Nature 436:876-880.
Zheng M, Li YM and Lau Y-FC (2013). Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-Chip studies. Methods in Molecular Biology, 1067:186-202.
Mpeak download here: Mpeak Program
Mpeak instructions download here: Mpeak Instructions
Data from Cell Reports Article