PUBLICATIONS (~125 peer-reviewed papers)

Oh HJ, Li YM and Lau Y-FC (2005). Sry associates with a gene-silencing complex by interacting with a KRAB domain protein. Biol Reprod, 72:407-415. [PubMed]

Taketo T, Lee C-H, Zhang JQ, Li YM, Lee G and Lau Y-FC (2005). Expression of Sry proteins in both normal and sex-reversed XY fetal mouse gonads. Devel Dyn, 233:612-622. [PubMed]

Williams K, Fernandex S, Stien X, Ishii K, Love HD, Lau Y-FC, Roberts RL and Hayward SW (2005). Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. The Prostate, 63:369-384. [PubMed]

Kido T and Lau Y-FC (2005). A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis, 42:263-275. [PubMed]

Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau Y-FC, Oosterhuis JW, Looijenga LH (2005). Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol, 36:512-21. [PubMed]

Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau Y-FC, Looijenga LH, Oosterhuis JW (2006). Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol, 208:395-400. [PubMed]

Oh HJ and Lau Y-FC (2006). KRAB: A partner for SRY action on chromatin. Mol Cell Endocrinol, 247:47-52. [PubMed]

Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau Y-FC, Drop SL, Looijenga LH (2006). Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol, 37:101-11. [PubMed]

Hoei-Hansen C, Sehested A, Juhler M, Lau Y-FC, Skakkebaek NE, Laursen H and Rajpert-De Meyts E (2006). New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Path, 209:25-33. [PubMed]

Oram SW, Liu XX, Lee T-L, Chan WY and Lau Y-FC (2006). TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer, 6: 154. [PubMed]

Vong QP, Li Y, Lau Y-FC, Dym M, Rennert OM, Chan WY (2006). Structural characterization and expression studies of Dby and its homologs in the mouse. J Andrology, 27:653-661. [PubMed]

Li YM, Oh HJ and Lau Y-FC (2006). Poly(ADP-ribose) polymerase I interacts with Sry and modulates its biological activities. Mol Cell Endocrin, 257-258:35-46. [PubMed]

Kido T and Lau Y-FC (2006). The rat Tspy is preferentially expressed in elongated spermatid and interacts with core histones, Biochem Biophys Res Comm, 250:56-67. [PubMed]

Li YM, Vilain E, Conte F, Rajpert-De Meyts E and Lau Y-FC (2007). TSPY is expressed in early and late stages of gonadoblastoma and testicular carcinoma-in-situ. Urol Oncol, 25:141-146 . [PubMed]

Oh HJ, Kido T and Lau Y-FC (2007). PIAS1 interacts with and represses SOX9 transactivation activity. Mol Reprod Develop, 74:1446-55. [PubMed]

Li YM, Tabatabi ZL, Lee T-L, Hatakeyama S, Ohyama C, Chan W-Y, Looijenga LH and Lau Y-FC (2007). The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors, Human Pathology, 38:1470-81. [PubMed]

de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau Y-FC, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. (2007). JKT-1 is not a human seminoma cell line. International J Andrology, 30:350-65. [PubMed]

Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. (2007). Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clinical Endocrin, 67:184-92. [PubMed]

Kido T and Lau Y-FC (2008). The human Y-encoded testis-specific protein interacts functionally with the translation elongation factor 1A, International Journal of Cancer, 123:1573-85.[PubMed]

Li YM and Lau Y-FC (2008). TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin dependent kinase 1 activities, Oncogene, 27:6141:50 [PubMed].

Li YM, Kido T, Luo S, Dobrinski I, and Lau Y-FC (2008). Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumors. International J Exp Pathology, 89:342-9. [PubMed]

Lau Y-FC and Li YM (2009). The human and mouse sex-determining SRY genes repress the Rspo1/β-catenin signaling. J Genomics Genet, 36:193-202. [PubMed]

Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau Y-FC, Chan WY. (2009). Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics, 36:215-27. [PubMed]

Lau Y-FC, Li YM and Kido T (2009). Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res C Embryo Today, 87:114-22. [PubMed]

Peng H, Ivanov AV, Oh HJ, Lau Y-FC, and Rauscher III FJ (2009). Epigenetuc gene silencing by the SRY protein is mediated by a KRAB-O protein which recruits the KAP1 co-repressor machinery. J Biol Chem, 284:35670-80. [PubMed]

Wu JB, Chen K, Li YM, Lau Y-FC and Shih JC (2009). Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J,23:4029-38. [PubMed]

Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau Y-FC and Chan WY (2010). GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics, 26:585-6.[PubMed]

Kido T, Hatakeyama S, Ohyama C and Lau Y-FC (2010). Expression of the Y-encoded TSPY is associated with progression of prostate cancer. Genes 1:283-293. [PubMed]

Lau Y-FC, Li YM and Kido T (2011). Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Systems Biol in Reprod Med, 57:27-34. [PubMed]

Kido T, Schubert S, Schmidtke J and Lau Y-FC (2011). Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions, J Genetics and Genomics 38:181-192. [PubMed]

Kido T, Ou JT-H, Lau Y-FC (2011). The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the ubiquitin-proteasome pathway, PLOS One, 6:e22979. [PubMed]

Li Y, Taketo T, Lau Y-FC (2012). Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Methods Mol Biol. 2012;825:3-16. [PubMed]

Zheng M, Li Y, Lau Y-FC (2013). Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. Methods Mol Biol. 1067:185-202. [PubMed]

Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau Y-FC (2014). Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. Cell Biosci. 4:9. [PubMed]

Kido T, Lau Y-FC (2014). The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochem Biophys Res Commun. 446:206-11. [PubMed]

Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau Y-FC (2014). The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Hum Pathol, 45:1847-58. [PubMed]

Li Y, Zheng M, Lau Y-FC (2014). The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation.Cell Reports, 8:723-33. [PubMed]

Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau Y-FC (2014). SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease.Hum Mol Genet. 24:685-97. {PubMed]

Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau Y-FC, Dahiya R and Tanaka Y (2015). Finctional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget, 6:16341-51. [PubMed]

Kido T and Lau Y-FC (2015). The roles of the Y chromosome genes in human cancers, Asian Journal of Andrology, 17:373-80. [PubMed]

Kido T and Lau Y-FC (2016). Identification of a TSPY-co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. J Genet Genomics, 43:577-585. [PubMed]

Li YM, Zhang JD, Qiu Y, Kido T and Lau Y-FC (2017). The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. Human Molecular Genetics, 26:901-912. [PubMed]

Kido T, Sun Z, and Lau Y-FC (2017). Aberrant activation of the sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice, Scientific Reports, 7:4113. [PubMed]

Lau Y-FC, Li YM and Kido T (2018). Battle of the Sexes: Contrasting Roles of TSPY and TSPX in Human Oncogenesis, Asian J. Andrology, in press.

BOOK CHAPTERS (11 book chapters)

Lau Y-FC, Kido T and Li YM (2007). TSPY family of multi-functional proteins. In Y Chromosome and Male Germ Cell Biology (Y-FC Lau and WY Chan, eds). World Scientific Press, New Jersey, pp73-90.

BOOKS (2 books)

Lau Y-FC and Chan W-Y (2007). Editors, Y Chromosome and Male Germ Cell Biology. World Scientific Press, New Jersey. []