Welcome to Chris Lau's Laboratory


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The Laboratory of Cell and Developmental Genetics

Yun-Fai Chris Lau, Ph.D.

Professor, Department of Medicine, University of California, San Francisco

Research Career Scientist, Veterans Affairs Medical Center, San Francisco

Member, Institute for Human Genetics, University of California, San Francisco

Member, Cancer Genetics & Prostate Cancer Program, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco

Member, Liver Center, University of California, San Francisco


Y Chromosome Genes in Health and Diseases

Our research focuses on understanding the roles of Y chromosome genes, and their homologues, in mammalian development and their epigenetic regulation and dysfunctions contributing to both normal male development and human diseases. Our research efforts are currently on the following specific areas of investigation:

  • Molecular mechanism of sex determination and differentiation - early stages of male sex differentation

  • Roles of the sex chromosomes in human cancers - how misbehavior of certain Y and X chromosome genes could exacerbate or suppress human tumor initiation and development

  • Y chromosome and sexual dimorphisms in normal development, disease initiation and progression - brain structure, neurodevelopment, neurodegeneration, cognitive disorders, autism and somatic cancers with sex differences, such as liver cancer.

  • Transgenic mouse models of human diseases

Various molecular genetics, genomics, proteomic and transgenic mouse strategies are utilized in our research.

Contact Information


Chris Lau, Ph.D.

Laboratory of Cell and Developmental Genetics

Department of Medicine

VA Medical Center, 111C5

University of California, San Francisco
4150 Clement Street

San Francisco, CA 94121

Telephone: 415-379-5526

Facsimile: 415-750-6633

E-mail: [email protected]

Laboratory: 415-221-4810 x3434 or 3314

Additional websites: http://cancer.ucsf.edu/people/lau_yun-fai.php

Society of Chinese Bioscientists in America: http://www.scbasociety.org/